PERK(Phospho Thr981) Polyclonal Antibody, 20ul Bottle-Top Dispenser It is ubiquitous

It is ubiquitous

PGR uses two distinct promotors and translation start sites in the first exon to produce several transcript variants

Mutations in this gene are associated with defects and cancers of the immune system

and participates in the MAP kinase-mediated signaling cascade

PERK(Phospho Thr981) Polyclonal Antibody, 20ul Bottle-Top Dispenser It is ubiquitousThe protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in