Smad5 Polyclonal Antibody, 100ul Glassware Sets PMID: 15805470)

PMID: 15805470)

This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate

PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis

Smad5 Polyclonal Antibody, 100ul Glassware Sets PMID: 15805470)Mothers against decapentaplegic homolog 5 encoded by SMAD5 is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants.