RCC1 Polyclonal Antibody, 50ul Vortex Mixer Mutations in this gene have

Mutations in this gene have been associated with Kenny-Caffey syndrome (KCS) type 2 and the more severe osteocraniostenosis (OCS| also known as Gracile Bone Dysplasia)| both characterized by short stature| hypoparathyroidism| bone development abnormalities| and hypocalcemia

in cells undergoing apoptosis

This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus

PPP1R3C (protein phosphatase 1 regulatory subunit 3C) encodes a regulatory subunit of protein phosphatase-1 (PP1)

RCC1 Polyclonal Antibody, 50ul Vortex Mixer Mutations in this gene haveThe Ras family small GTPase Ran is involved in nuclear envelope formation, assembly of the mitotic spindle and nuclear transport. Like other small GTPases, Ran is active in its GTP bound form and inactive in its GDP bound form. Nuclear RanGTP concentration is maintained through nuclear localization of guanine nucleotide exchange factor (GEF) activity, which catalyzes the exchange of bound GDP for GTP. RCC1 (regulator of chromatin condensation 1) is