Tuberin/TSC2(Phospho-Ser1387) Rabbit Polyclonal Antibody, 100ul Liquid Storage Consumables eukaryotic translation elongation factor 1

eukaryotic translation elongation factor 1 alpha 1 is identified as an autoantigen in 66% of patients with Felty syndrome

The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein

The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA

Also functions as a receptor for various alkaloids and psychoactive substances

Tuberin/TSC2(Phospho-Ser1387) Rabbit Polyclonal Antibody, 100ul Liquid Storage Consumables eukaryotic translation elongation factor 1Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.