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p57(Phospho Thr310) Polyclonal Antibody, 100ul Aspirating Pipets Calcium-dependent

SKU: 21244138705

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p57(Phospho Thr310) Polyclonal Antibody, 100ul Aspirating Pipets Calcium-dependentThis gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight binding, strong inhibitor of several G1 cyclin Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

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Description

Calcium-dependent

Pseudogenes of this gene are present on chromosomes 1| 3| 9| 12 and 20| and on the X chromosome

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The WW domains are essential for localization to nuclear speckles

p57(Phospho Thr310) Polyclonal Antibody, 100ul Aspirating Pipets Calcium-dependentThis gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight binding, strong inhibitor of several G1 cyclin Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

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