OPA1 Polyclonal Antibody, 50ul Diagnostic Probes & Oligos Individual members of this family

Individual members of this family differ in the number of C-terminal TS motifs

Sequence analysis identified two transcript variants that encode the same protein

The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain

it is required to recruit USP22 and ENY2 into the SAGA complex

OPA1 Polyclonal Antibody, 50ul Diagnostic Probes & Oligos Individual members of this familyThis gene product is a nuclear encoded mitochondrial protein with similarity to dynamin related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.