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Gab 2(Phospho Ser159) Polyclonal Antibody, 100ul Polyclonal Antibodies Mutations in TH have been

SKU: 23693730250

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Gab 2(Phospho Ser159) Polyclonal Antibody, 100ul Polyclonal Antibodies Mutations in TH have beenThis gene is a member of the GRB2 associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T and B cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol 3 kinase in

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Description

Mutations in TH have been associated with autosomal recessive Segawa syndrome

where it regulates integrin-mediated signal transduction

and cell migration

The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha)

Gab 2(Phospho Ser159) Polyclonal Antibody, 100ul Polyclonal Antibodies Mutations in TH have beenThis gene is a member of the GRB2 associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T and B cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol 3 kinase in

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