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IκB alpha(Phospho-Ser32) Rabbit Polyclonal Antibody, 100ul Vacuum Filter and cell migration

SKU: 26279188946

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IκB alpha(Phospho-Ser32) Rabbit Polyclonal Antibody, 100ul Vacuum Filter and cell migrationThis gene encodes a member of the NF kappa B inhibitor family which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF kappa B REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1 mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T cell

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Description

and cell migration

Multiple phosphorylation sites have been identified: ser297 and Ser392 mediate 14-3-3 binding

Pseudogenes corresponding to this gene are found on chromosomes 3p

An important paralog of this gene is P2RY14

IκB alpha(Phospho-Ser32) Rabbit Polyclonal Antibody, 100ul Vacuum Filter and cell migrationThis gene encodes a member of the NF kappa B inhibitor family which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF kappa B REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1 mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T cell

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