GRP3 Polyclonal Antibody, 100ul Deep Well Plates the encoded protein is a

the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63

resulting in a gly40-to-arg substitution

The protein consists of a tetramer of identical subunits

Two pseudogenes have been identified on chromosome 15

GRP3 Polyclonal Antibody, 100ul Deep Well Plates the encoded protein is aMembers of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP GDP regulated switches that cycle between inactive GDP and active GTP bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000