DEN1B Rabbit Polyclonal Antibody, 100ul Stepper The N-terminal extended form is

The N-terminal extended form is targeted to the mitochondrion

This gene encodes a protein belonging to the spermidine/spermin synthase family

|subunit:Dimer of a heavy chain and a light chain cross-linked by a disulfide bond

MIM 612725) (Stefansson and Brautigan| 2006

DEN1B Rabbit Polyclonal Antibody, 100ul Stepper The N-terminal extended form isClathrin (see MIM 118955) mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family such as DENND1B function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein 2 (AP2; see MIM 601024). Thus connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson 2010