FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody, 50ul Cell Function Analysis subunit:Interacts (via SH3 domain) with

subunit:Interacts (via SH3 domain) with COL7A1

The protein lacks critical active site residues and thus is suggested to be proteolytically inactive

as well as fetal brain and liver and hematopoietic cell lines

subunit:Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4

FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody, 50ul Cell Function Analysis subunit:Interacts (via SH3 domain) withdisease: A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X; 11)(q13; q23) with MLL HRX. The result is a rogue activator protein. Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin response elements (IREs) and can activate transcription of IGFBP1. Down regulates expression of HIF1A and suppresses hypoxia induced transcriptional activation of HIF1A modulated genes.