NEDD4L(Phospho-Ser342) Rabbit Polyclonal Antibody, 100ul Sampling Tubes Mutations in RAF1 are associated

Mutations in RAF1 are associated with Noonan syndrome 5 and LEOPARD syndrome 2

The encoded protein is a kinase that can be inactivated by hemin

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also known as TOME1 (Trigger of mitotic entry protein 1) and GRCC8 (Gene-rich cluster protein C8)

NEDD4L(Phospho-Ser342) Rabbit Polyclonal Antibody, 100ul Sampling Tubes Mutations in RAF1 are associatedThis gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin conjugating enzymes to protein substrates thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial