Stat5 Polyclonal Antibody, 50ul[BT-AP08635] Serum Multiple transcript variants encoding different

Multiple transcript variants encoding different isoforms have been found for CALCA

This gene product acts as a GEF preferentially for RhoG

A pseudogene of this gene is located on the long arm of chromosome 5

where it is present on the brush border of proximal tubules and on glomerular epithelium

Stat5 Polyclonal Antibody, 50ul[BT-AP08635] Serum Multiple transcript variants encoding differentStat5 is activated in response to a wide variety of ligands including IL 2, GM CSF, growth hormone and prolactin. Phosphorylation at Tyr694 is obligatory for Stat5 activation. This phosphorylation is mediated by Src upon erythropoietin stimulation. Stat5 is constitutively active in some leukemic cell types. Phosphorylated Stat5 is found in some endothelial cells treated with IL 3, which suggests its involvement in angiogenesis and cell motility.