SAFB2 Rabbit Polyclonal Antibody, 100ul Glassware SIK is activated by phosphorylation

SIK is activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-alpha and CAB39

Plays a role in the control of regulated secretion in neural and endocrine cells

The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities

and auxiliary subunits alpha-2/delta

SAFB2 Rabbit Polyclonal Antibody, 100ul Glassware SIK is activated by phosphorylationThe protein encoded by this gene along with its paralog (scaffold attachment factor B1) is a repressor of estrogen receptor alpha. The encoded protein binds scaffold matrix attachment region (S MAR) DNA and is involved in cell cycle regulation apoptosis differentiation the stress response and regulation of immune genes.