MDMX(Phospho Ser367) Polyclonal Antibody, 50ul Immunoassays Catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor =

Catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor

This gene encodes a member of the BTB-kelch superfamily

most often results in early miscarriage but is occasionally seen in a mosaic form in surviving patients who suffer to a varying degree from a number of symptoms including retarded mental and motor development

This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator

MDMX(Phospho Ser367) Polyclonal Antibody, 50ul Immunoassays Catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor =This gene encodes a nuclear protein that contains a p53 binding domain at the N terminus and a RING finger domain at the C terminus, and shows structural similarity to p53 binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation