TRY6 Rabbit Polyclonal Antibody, 50ul Glassware Sets Targeted to sites of DNA

Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair

It is thought that this secreted protein contains antitumor activity

The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B

This is supported by studies in knockout mice showing development of soft-tissue sarcomas| ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen

TRY6 Rabbit Polyclonal Antibody, 50ul Glassware Sets Targeted to sites of DNAAlthough this locus appears to encode a protein similar to trypsinogen the locus is thought to be a transcribed pseudogene. ESTs support its transcription but expression of its predicted protein has not been observed. Its predicted protein sequence differs significantly from the known functional trypsinogens including a different amino acid at the conserved residue 122 which is important for autolysis. This pseudogene and several other trypsinogen