Ezrin(Phospho Tyr353) Polyclonal Antibody, 20ul Sample Library Tubes Mutations in this gene are

Mutations in this gene are a cause of colorectal cancer (CRC)

Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events

such as RAPGEF5 (Rap guanine nucleotide exchange factor 5)

which accumulate at focal adhesions and are also involved in the regulation of the actin cytoskeleton

Ezrin(Phospho Tyr353) Polyclonal Antibody, 20ul Sample Library Tubes Mutations in this gene areThe cytoplasmic peripheral membrane protein encoded by this gene functions as a protein tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been