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PFKM Polyclonal Antibody, 50ul CellSafe™ The encoded mechanosensing protein (catenin

SKU: 39246656514

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EUR162.00 EUR185.00

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PFKM Polyclonal Antibody, 50ul CellSafe™ The encoded mechanosensing protein (cateninThree phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose 6 phosphate to fructose 1,6 bisphosphate. Tetramer composition varies depending on tissue type. PFKM encodes the muscle type isozyme. Mutations in PFKM have been associated with glycogen storage disease type VII, also known as Tarui disease.

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Description

The encoded mechanosensing protein (catenin alpha 1) contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension

it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins

It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3

Microtubules maintain cellular structure

PFKM Polyclonal Antibody, 50ul CellSafe™ The encoded mechanosensing protein (cateninThree phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose 6 phosphate to fructose 1,6 bisphosphate. Tetramer composition varies depending on tissue type. PFKM encodes the muscle type isozyme. Mutations in PFKM have been associated with glycogen storage disease type VII, also known as Tarui disease.

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