VAPA Rabbit Polyclonal Antibody, 50ul Culture Tubes Binds to the signal sequence

Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein)

This protein is overexpressed in fetal Down syndrome brain

It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix

and microtubule assembly

VAPA Rabbit Polyclonal Antibody, 50ul Culture Tubes Binds to the signal sequenceThe protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking membrane fusion protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.