DYRK3 Polyclonal Antibody, 20ul Custom DNA Oligos JUP encodes a major cytoplasmic

JUP encodes a major cytoplasmic protein (junction plakoglobin) which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions

Mutation of this gene is associated with acute myeloid leukemia

but the full-length nature for every variant has not been determined

tissue specificity:Expressed abundantly in the lung and neutrophils

DYRK3 Polyclonal Antibody, 20ul Custom DNA Oligos JUP encodes a major cytoplasmicThis gene product belongs to the DYRK family of dual specificity protein kinases that catalyze autophosphorylation on serine threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in