ARK-1 Polyclonal Antibody, 50ul[BT-AP00610] Modification Enzymes |disease:In B-cell leukemia (B-CLL) cell

|disease:In B-cell leukemia (B-CLL) cell line| LB40 and EB308| can be found after heterogeneous chromosomal aberrations| such as internal deletions

The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor

In vivo activation of TAK1 requires association with TAK1 binding protein 1 (TAB1)

The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin

ARK-1 Polyclonal Antibody, 50ul[BT-AP00610] Modification Enzymes |disease:In B-cell leukemia (B-CLL) cellThe protein encoded by AURKA is a cell cycle regulated kinase that appears to be involved in microtubule formation and or stabilization at the spindle pole during chromosome segregation. The encoded protein (aurora kinase A) is found at the centrosome in interphase cells and at the spindle poles in mitosis. AURKA may play a role in tumor development and progression. A processed pseudogene of AURKA has been found on chromosome 1, and an unprocessed