SPAK(Phospho Ser323) Polyclonal Antibody, 100ul Shakers Ribosomal 40S and 60S subunits

Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm

further cleavages takes place in the heavy chain

tissue specificity:Expressed in brain and to a lesser extent in heart

This protein contains two phosphotyrosine binding (PTB) domains

SPAK(Phospho Ser323) Polyclonal Antibody, 100ul Shakers Ribosomal 40S and 60S subunitsThis gene encodes a serine threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation chloride coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the