UBP46 Polyclonal Antibody, 20ul Sample Library Tubes Deficiencies in this protein's function

Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases

This gene encodes a protein with two leucine zipper domains

This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin| which may serve as a mediator of granule-mediated apoptosis

As such| it may play a role in anti-viral immunity

UBP46 Polyclonal Antibody, 20ul Sample Library Tubes Deficiencies in this protein's functionModification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004