Raf-1(Phospho Ser338) Polyclonal Antibody, 100ul Immune Repertoire Sequencing Two pseudogenes of this gene

Two pseudogenes of this gene have been identified on chromosomes 10 and 4

Expressed in 22% of melanomas

This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed| developmentally down-regulated 9)

a conformational change is induced in the protein which traps the proteinase

Raf-1(Phospho Ser338) Polyclonal Antibody, 100ul Immune Repertoire Sequencing Two pseudogenes of this geneThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.