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LAT Polyclonal Antibody, 100ul[BT-AP04957] Cell Function Analysis Mutations in this gene are

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LAT Polyclonal Antibody, 100ul[BT-AP04957] Cell Function Analysis Mutations in this gene areLinker for activation of T cells family member 1 encoded by LAT is phosphorylated by ZAP 70 Syk protein tyrosine kinases following activation of the T cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular

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Description

Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN)

possibly functioning in heterochromatin interactions

This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5)

which is often found in patients with chronic myelogenous leukemia

LAT Polyclonal Antibody, 100ul[BT-AP04957] Cell Function Analysis Mutations in this gene areLinker for activation of T cells family member 1 encoded by LAT is phosphorylated by ZAP 70 Syk protein tyrosine kinases following activation of the T cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular

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