Vav1(Phospho Tyr174) Polyclonal Antibody, 20ul Nucleic Acid Extraction Pituitary tumor-transforming 1 is a

Pituitary tumor-transforming 1 is a homolog of yeast securin proteins

This gene encodes a member of the AGC serine/threonine kinase family of proteins

for sodium-coupled transport of a variety of organic and inorganic molecules

Several transcript variants encoding different isoforms have been described for this gene

Vav1(Phospho Tyr174) Polyclonal Antibody, 20ul Nucleic Acid Extraction Pituitary tumor-transforming 1 is aThis gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T cell and B cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV 1.