HEXA Polyclonal Antibody, 100ul Antibody Humanization collagen XIII contains a transmembrane

collagen XIII contains a transmembrane domain and the protein has been localized to the plasma membrane

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is a specific SUMO-E3 ligase for Ets-1 and represses Ets-1 dependent transcription

Multiple mutations in this gene have been identified

HEXA Polyclonal Antibody, 100ul Antibody Humanization collagen XIII contains a transmembraneHEXA encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons,