IGFBP3 Polyclonal Antibody, 50ul[BT-AP04388] Reservoirs The proline-rich domain may interact

The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding

promotion of angiogenesis

liver and brain but not in other tissues

the disabled-1 gene plays a central role in brain development

IGFBP3 Polyclonal Antibody, 50ul[BT-AP04388] Reservoirs The proline-rich domain may interactIGFBP3 is a member of the insulin like growth factor binding protein (IGFBP) family and encodes Insulin like growth factor binding protein 3 with an IGFBP domain and a thyroglobulin type I domain. The protein forms a ternary complex with insulin like growth factor acid labile subunit (IGFALS) and either insulin like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half life of IGFs and altering their interaction