BRMS-1 Polyclonal Antibody, 50ul[BT-AP00979] Gene Synthesis Mutations in this gene cause

Mutations in this gene cause karyomegalic interstitial nephritis

AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites

This major histocompatibility complex gene represents a transcribed pseudogene

A recent study showed this gene to be an authentic stop codon readthrough target| and that its mRNA can give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon

BRMS-1 Polyclonal Antibody, 50ul[BT-AP00979] Gene Synthesis Mutations in this gene causeBRMS1 reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. Breast cancer metastasis suppressor 1 encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different