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Rb(Phospho Ser795) Polyclonal Antibody, 50ul Syringe Filter Pseudogenes have been identified on

SKU: 50137641685

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Rb(Phospho Ser795) Polyclonal Antibody, 50ul Syringe Filter Pseudogenes have been identified onThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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Description

Pseudogenes have been identified on chromosomes 2 and 12

Both proteins bind the p53 tumor suppressor protein and inhibit its activity

In tumor microenvironments

Additional alternatively spliced transcript variants of DYRK4 have been described

Rb(Phospho Ser795) Polyclonal Antibody, 50ul Syringe Filter Pseudogenes have been identified onThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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