CBX2 Polyclonal Antibody, 20ul Sampling Tubes Alternate splicing of CTSH results

Alternate splicing of CTSH results in multiple transcript variants encoding different isoforms

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Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers

and three alternative downstream AUG initiation codons

CBX2 Polyclonal Antibody, 20ul Sampling Tubes Alternate splicing of CTSH resultsCBX2 (chromobox 2) encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of CBX2 in mice results in male to female gonadal sex reversal. Mutations in CBX2 are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms