FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody, 20ul 3D Culture The protein is weakly similar

The protein is weakly similar to transposase-like proteins in human and mouse

Two alternatively spliced transcript variants encoding distinct isoforms have been described

The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs)| and functions as a mediator of the anti-apoptotic signals from TNF receptors

An important paralog of this gene is SLC38A1

FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody, 20ul 3D Culture The protein is weakly similardisease: A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X; 11)(q13; q23) with MLL HRX. The result is a rogue activator protein. Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin response elements (IREs) and can activate transcription of IGFBP1. Down regulates expression of HIF1A and suppresses hypoxia induced transcriptional activation of HIF1A modulated genes.