Shc(Phospho-Ser239/240) Rabbit Polyclonal Antibody, 100ul Thermal Control MAP kinases

MAP kinases

The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins

This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor

It is also involved in the immune response| and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification

Shc(Phospho-Ser239/240) Rabbit Polyclonal Antibody, 100ul Thermal Control MAP kinasesThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms p52Shc and p46Shc link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in Ras activation. Unlike