Topo IIIBeta-1 Polyclonal Antibody, 50ul Micro Centrifuge Tubes Mutations in this gene are

Mutations in this gene are associated with Turner type X-linked syndromic mental retardation

GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase regulator activity

and mutations in SCNN1B have been associated with pseudohypoaldosteronism type 1 (PHA1)

Belongs to the EBP2 family

Topo IIIBeta-1 Polyclonal Antibody, 50ul Micro Centrifuge Tubes Mutations in this gene areTOP3B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome