KDM5B Polyclonal Antibody, 20ul Lysosome The expression of this gene

The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis

Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression

Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis

Also phosphorylated on Ser-524 independently of reelin signaling

KDM5B Polyclonal Antibody, 20ul Lysosome The expression of this geneThis gene encodes a lysine specific histone demethylase that belongs to the jumonji ARID domain containing family of histone demethylases. The encoded protein is capable of demethylating tri , di and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair.