SHP-1(Phospho-Tyr564) Rabbit Polyclonal Antibody, 20ul Cellular Function Assays Desmosomes are cell-cell junctions that

Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress

an arg-gly-asp integrin association motif

The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway| and transcription of the two genes is coordinately regulated

disease:Defects in COL4A1 are a cause of brain small vessel disease with hemorrhage

SHP-1(Phospho-Tyr564) Rabbit Polyclonal Antibody, 20ul Cellular Function Assays Desmosomes are cell-cell junctions thatThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitotic cycle and oncogenic transformation. N terminal part of this PTP contains two tandem Src homolog (SH2) domains which act as protein phospho tyrosine binding domains and mediate the interaction of this PTP with its substrates.