Tuberin/TSC2(Phospho-Ser1254) Rabbit Polyclonal Antibody, 50ul Serum The N-terminus is poorly conserved

The N-terminus is poorly conserved and may impart additional roles in developmental regulation

a pseudogene of SRSF11 has been found on chromosome 12

there are multiple processed pseudogenes of this gene dispersed throughout the genome

PIAS1 encodes a member of the protein inhibitor of activated STAT (PIAS) family

Tuberin/TSC2(Phospho-Ser1254) Rabbit Polyclonal Antibody, 50ul Serum The N-terminus is poorly conservedMutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.