ErbB-3 Polyclonal Antibody, 100ul[BT-AP03039] Antibody Humanization Mutations in this gene result

Mutations in this gene result in incontinentia pigmenti| hypohidrotic ectodermal dysplasia| and several other types of immunodeficiencies

thymus and peripheral blood

An alternative splice variant has been described but its full length sequence has not been determined

The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein

ErbB-3 Polyclonal Antibody, 100ul[BT-AP03039] Antibody Humanization Mutations in this gene resultERBB3 encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation