LRP1 Polyclonal Antibody, 20ul Site-directed Mutagenesis Polymorphisms in CHAT have been

Polymorphisms in CHAT have been associated with Alzheimer's disease and mild cognitive impairment

and therefore this allele is pseudogenic due to the failure to produce a functional full-length protein

thus passing the substrate from one enzyme to another

Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm

LRP1 Polyclonal Antibody, 20ul Site-directed Mutagenesis Polymorphisms in CHAT have beenLRP1 encodes a member of the low density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2 macroglobulin