MAGD1 Polyclonal Antibody, 100ul Drug Development and Evaluation Overactivation of type I interferon

Overactivation of type I interferon secretion is linked to autoimmune diseases

fatty liver

Constitutive activation of this gene caused either by somatic mutations| or genomic duplications of regions that include this gene| have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome

Despite its single-exon nature| this chromosome 5 locus contains an open reading frame that could putatively encode a full-length germ cell-less related protein

MAGD1 Polyclonal Antibody, 100ul Drug Development and Evaluation Overactivation of type I interferonThis gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death