Phospho-Akt (S473) mouse Monoclonal Antibody(7F9), 100ul Gene Synthesis PTM:May be sumoylated

PTM:May be sumoylated

It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function

thus| it functions as a regulator of a wide variety of downstream proteins| including tumor suppressor proteins p53 and BRCA1| checkpoint kinase CHK2| checkpoint proteins RAD17 and RAD9| and DNA repair protein NBS1

and E3) of the large pyruvate dehydrogenase complex

Phospho-Akt (S473) mouse Monoclonal Antibody(7F9), 100ul Gene Synthesis PTM:May be sumoylatedThe serine threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3 kinase. In the developing nervous system AKT is a