Crk-L Monoclonal Antibody, 100ul Buffers & Solutions Mutations in this gene are

Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis

Gene Ontology (GO) annotations related to PRDM12 include methyltransferase activity

phosphorylate and repress the activity of E47

including interleukin 28A (IL28A)

Crk-L Monoclonal Antibody, 100ul Buffers & Solutions Mutations in this gene areThis gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS dependent fashion. It is a substrate of the BCR ABL tyrosine kinase, plays a role in fibroblast transformation by BCR ABL, and may be oncogenic.