IRF-3 Polyclonal Antibody, 20ul[BT-AP04627] Shakers Chromosomal rearrangements and altered expression

Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis

It is glycosylated postranslationally and localized to the golgi apparatus

which may be involved in regulatory processes important for development and cellular differentiation

Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera

IRF-3 Polyclonal Antibody, 20ul[BT-AP04627] Shakers Chromosomal rearrangements and altered expressionIRF3 encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed