Histone H1 Polyclonal Antibody, 50ul[BT-AP03992] Plasma Tay-Sachs disease is a lethal

Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene

This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression

it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration

Encoded by a gene that maps to human chromosome 7q34

Histone H1 Polyclonal Antibody, 50ul[BT-AP03992] Plasma Tay-Sachs disease is a lethalHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.