Cortactin(Phospho Tyr421) Polyclonal Antibody, 50ul Cellular Cultivation & Health Management Homeodomain-interacting protein kinase 4 lacks

Homeodomain-interacting protein kinase 4 lacks a nuclear localization signal and a C-terminal autoinhibitory domain

acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs

Part of a complex consisting of SFPQ

Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2)

Cortactin(Phospho Tyr421) Polyclonal Antibody, 50ul Cellular Cultivation & Health Management Homeodomain-interacting protein kinase 4 lacksThis gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase