Raf-1 Polyclonal Antibody, 50ul[BT-AP13535] In vitro Assessment Multiple alternatively spliced transcript variants

Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed

The importance of the iron binding function has not yet been identified

The protein encoded by DDR1 (discoidin domain receptor tyrosine kinase 1) belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain

EDNRA encodes the receptor for endothelin-1

Raf-1 Polyclonal Antibody, 50ul[BT-AP13535] In vitro Assessment Multiple alternatively spliced transcript variantsThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.