ADA11 Rabbit Polyclonal Antibody, 50ul Molecular Sciences The E3 ubiquitin-protein ligase activity

The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1

This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus

and is alternatively translated from non-AUG (CUG) and AUG initiation codons

alpha 1 are both subject to copy number variation

ADA11 Rabbit Polyclonal Antibody, 50ul Molecular Sciences The E3 ubiquitin-protein ligase activityThis gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell cell and cell matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature