NEK6 Polyclonal Antibody, 100ul Enzymes The cyclin dependent kinase inhibitor

The cyclin dependent kinase inhibitor 1B binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes

and a 74-amino acid cytoplasmic domain

|The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion| thus inhibiting the enzyme

a N-terminal I-band and a C-terminal A-band

NEK6 Polyclonal Antibody, 100ul Enzymes The cyclin dependent kinase inhibitorThe protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene.