Bcr Polyclonal Antibody, 50ul[BT-AP00878] Apoptosis & Autophagy POLE2 (Polymerase (DNA) Epsilon 2

POLE2 (Polymerase (DNA) Epsilon 2

The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex

3 ubiquitin-protein ligase

Among its related pathways are Bacterial invasion of epithelial cells and ERK Signaling

Bcr Polyclonal Antibody, 50ul[BT-AP00878] Apoptosis & Autophagy POLE2 (Polymerase (DNA) Epsilon 2A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR ABL fusion protein has been extensively studied, the