Rat Glypican-3, GPC-3 ELISA Kit, 96T Electronic Pipette Mutations in TUBA1A cause lissencephaly

Mutations in TUBA1A cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly

mitotic checkpoint protein) contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein

PTM:Phosphorylated on tyrosine residues in response to EGF and PDGF

tumor invasion

Rat Glypican-3, GPC-3 ELISA Kit, 96T Electronic Pipette Mutations in TUBA1A cause lissencephalyCell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical